![]() ![]() The nontuberculous Mycobacteria (NTM) are a group of microorganisms that is very common in chronic pulmonary diseases. Any articles with this theme, reporting bacterial pathogen associated with CF patients with no distinction of sex and age were selected and only the articles describing pathogens and the antibiotic therapy were really used. The uniterms Cystic fibrosis, infection and antibiotic therapy were used in a retrospective search between 1990 to 2007. For this objective, a systematic search was conducted using the international bibliographic databanks SCIELO, HIGHWIRE, PUBMED, SCIRUS and LILACS. ![]() ĭue to this succession of bacterial populations in CF patients and due to the importance of these pathogens in prognosis, the objective of this article was to review and identify known and emerging bacterial pathogens associated with pulmonary problems and involved with cystic fibrosis. aureus in 63.3%, Haemophilus influenzae in 16.6%, Stenotrophomonas maltophilia in 15% and nontuberculous Mycobacteria (NTM) in 13.3%. aeruginosa in 50% of these individuals, S. In Germany, analysis of the sputum from CF patients during a period of 12 months showed the presence of P. ĭuring the first decade of life of CF patients, Staphylococcus aureus and Hemophilus influenzae are the most common bacteria isolated from the sputum, but in the second and third decade of life, Pseudomonas aeruginosa is the prevalent bacteria. Failure of innate defense mechanisms and the lack of mucocilliary clearance in the airways stimulate primary and recurrent bacterial infections, blockage of airways, inflammation and chronic bacterial infections. ![]() This disease affects persons without distinction of age or sex but can be asymptomatic in a great number of cases. The persons affected die by progressive bronchiectasis and chronic respiratory insufficiency. Its high mortality index is evident when lung and spleen are affected, but other organs can also be affected. This disease is caused by mutations affecting the cystic fibrosis conductance regulator protein (CFTR) and is characterized by chronic lung malfunction, pancreatic insufficiency and high levels of chloride in sweat. Therefore, these pathogens should be pointed out as a risk to these patients, and hospitals all over the world must be prepared to detect and combat these bacteria.Ĭystic fibrosis (CF) is the most common autosomal genetic disease in North America, affecting 1:2000 Caucasian individuals. However, healthcare professionals must pay attention to emerging infectious agents in these patients, because they represent a potentially serious future problem. aureus are the most important infectious agents in cystic fibrosis patients. A systematic search was conducted using the international bibliographic databanks SCIELO, HIGHWIRE, PUBMED, SCIRUS and LILACS to provide a useful and practical review for healthcare workers to make them aware of these microorganisms. The objective of this review was to describe the bacterial pathogens colonizing patients with cystic fibrosis. The most serious symptoms are observed in the lungs, augmenting the risk of bacterial infection. Cystic fibrosis is the most common and best known genetic disease involving a defect in transepithelial Cl- transport by mutations in the CF gene on chromosome 7, which codes for the cystic fibrosis transmembrane conductance regulator protein (CFTR). ![]()
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